Elsevier

Psychiatry Research

Volume 218, Issues 1–2, 15 August 2014, Pages 249-251
Psychiatry Research

Brief report
Initial and post-treatment total oxidant–antioxidant status and oxidative stress index in male patients with manic episode

https://doi.org/10.1016/j.psychres.2014.04.021Get rights and content

Abstract

We investigated serum total oxidative and anti-oxidative status in manic patients. Group1 was formed as ECT+antipsychotic, group2 was antipsychotic and healthy volunteers as group3. The anti-oxidative status was significantly lower in group1 than group3. No significant change was found between pre and post-treatment oxidative and anti-oxidative status, whereas significantly increased oxidative stress index has been found in group2. Total anti-oxidative status in manic states seems to be inadequate which remains to be maintained after the treatment.

Introduction

A balance between oxidative and antioxidative systems is proposed in organism and oxidative stress has been revealed in the pathophysiology of some psychiatric disorders including bipolar affective disorder (Gergerlioglu et al., 2007). In addition, the above mentioned oxidative imbalance is thought to be improved in euthymic state (Savas et al., 2006) or after appropriate treatment (Selek et al., 2008). However, there is no clinical study about the influences of electroconvulsive treatment (ECT) on oxidative or antioxidative status in patients with manic episode.

We aimed to investigate serum TAS, TOS and OSI levels in patients with manic episode and the influences on TAS, TOS and OSI levels.

Section snippets

Participants

The screening phase of the participants and exclusion criteria were detailed in our previous study (Emul et al., 2013). The patients (n=68) were divided into two groups: antipsychotic group (AP, n=46; standardized as haloperidol 10–30 mg/daily+quetiapine 100–900 mg/daily) and ECT group (n=22); standardized treatment+ECT. Additionally, 30 age, gender matched healthy controls were enrolled in the study. Dose of antipsychotics were arranged according to severity of symptoms and response to the

Results

There were no significances between patients and healthy controls among age (34.76±10.63 vs 30.97±7.66, years p=0.115), smoking status, and education level, marital and working status. The TAS level of healthy controls was higher than that of the patients (p=0.002) while no significant differences were detected according to the TOS and OSI levels (p=0.330 and 0.459 respectively). The difference in TAS levels between patients and healthy controls after treatment remained significant (p=0.002).

Discussion

Investigation about the relation between serum TAS, TOS levels and manic state or treatment is lacking. Only in one study the serum TAS level was reported to be higher in euthymic phase of patients with BD than healthy controls (Yumru et al., 2009). There are several inconclusive results on antioxidant enzyme levels (i.e., superoxide dismutase, SOD; catalase, CAT and glutathione peroxidase, GSH-Px etc.) in manic episode: higher SOD level (Andreazza et al., 2007), higher SOD and CAT levels in 30

Conclusion

Antioxidative system in manic states seems to be inadequate which remains to be maintained after treatment. Antipsychotic drugs might increase oxidative stress and ECT may have positive or at least no additional influences on oxidative stress while treating mania.

Acknowledgments

The authors would like to thank to Dr. Sevgi Gebedek, Dr. Melike Beskoc and all colleagues working in the laboratory of Bakirkoy Mental Health Research and Training Hospital.

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