Progress and challenges of selective Farnesoid X Receptor modulation
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Keywords
FXR
SBARM
Dissociated ligand
Tissue-specific
NASH
IBD
Abbreviations
AF1
activation function 1 (domain)
BSEP
bile salt export pump
CAR
constitutive androstane receptor
CDCA
chenodeoxycholic acid
FXR
farnesoid x receptor
GR
glucocorticoid receptor
GS
guggulsterone
HCC
hepatocellular carcinoma (HCC)
IBD
inflammatory bowel disease
LBD
ligand-binding domain
MF
mometasone furoate
NAFLD
non-alcoholic fatty liver disease
NASH
non-alcoholic steatohepatitis
NF-κB
nuclear factor kappa b
NR
nuclear receptor
OCA
obeticholic acid
PBC
primary biliary cholangitis
PSC
primary sclerosing cholangitis
PK
pharmacokinetic
PUFA
polyunsaturated fatty acid
RXR
retinoid x receptor
SAR
structure-activity relationship
SBARM
selective bile acid receptor modulator
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These authors contributed equally to this work
© 2018 The Authors. Published by Elsevier Inc.