Original ArticleThe spectrum of glomerular disease between the years 2003 and 2015 in Columbia: A review of 12,613 casesEl espectro de enfermedades glomerulares entre los años 2003 y 2015 en Colombia: una revisión de 12.613 casos
Introduction
Renal biopsy is the gold standard for the diagnosis of glomerular disease (GD) as it provides precise information about clinical behavior which influences mortality and morbidity.1 Currently, primary GDs are a major problem in clinical nephrology and currently the fourth cause of end-stage renal disease (ESRD) worldwide.1, 2 Among patients in renal replacement therapy, primary glomerulopathies, diabetic nephropathy, nephrosclerosis, angioesclerosis and interstitial nephritis are the main causes of end-stage renal disease (ESRD).2 The prevalence of GD varies according to different socio-demographic characteristics, in Europe and North-America the most common causes are focal segmental glomerulosclerosis (FSGS) and IgA nephropathy (IGAN).1, 3 However, descriptive statistics related to GD are not well known. The aim of this study was to describe the prevalence of GD in the biggest cohort of renal biopsies reported to date.
Section snippets
Materials and methods
We analyzed retrospectively kidney biopsies, studied in our center and diagnosed as GD, during the period January 2003 to August 2015. All cases were processed according to the recommendations previously exposed by Walker et al.4 and evaluated by light microscopy, immunofluorescence and electron microscopy. Cases diagnosed as interstitial, tubular disease and conditions where the main damage was related with arterial or arteriolar vascular injury were excluded. A final sample of 12,613
Results
GD was more prevalent in adults, 78.6% (9911) and in females, 55.8% (7036). Amongst adults, the majority of patients were female, 57.4% (5692) whereas amongst children males were slightly predominant, 50.2% (1358) (Table 2). Of the 12,613 biopsies reported as GD, 82% cases corresponded to 5 histologic types; FSGS, IGAN, lupus nephritis, membranous glomerulonephritis and thin basement membrane disease. FSGS was the most common GD in children and IGAN in adults (Table 3).
Discussion
The epidemiology of renal diseases is linked to socio-demographic factors and although GD is considered a common cause of ESRD, it can be prevented with early diagnosis. Current research related to renal pathology focuses on ESRD with little available information regarding GD. To our knowledge, this is the first systematic review of histological data among a Latin-American population. Our data, collected over almost 12 years, records the prevalence of primary GD diagnosed in our pathology
Protection of human and animal subjects
The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association (Declaration of Helsinki).
Confidentiality of data
The authors declare that they have followed the protocols of their work center on the publication of patient data.
Right to privacy and informed consent
The authors declare that no patient data appear in this article.
Conflict of interest
The authors declare that there is no conflict of interests regarding the publication of this article.
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Spanish Registry of glomerulonephritis 2020 revisited: past, current data and new challenges
2020, NefrologiaCitation Excerpt :Finally, some studies have focused on certain age groups such as the child population in China83 and South Asia63 or in patients ≥ 60 years in Chicago,68 ≥ 65 in Ireland,45 Japan84 and Turkey85 and in ≥ 80 years in Japan86 and USA87. National or multicenter registries are the most reliable to know the epidemiology of biopsied kidney diseases and allow comparisons; in Table 1, are indicated most of these studies, including those made in the UK,88–91 France,92,93 New Caledonia,94 Italy,95–101 India,102 United Arab Emirates,103 Japan,104–118 Denmark,119,129 Singapore,121 Peru,122 Australia,123 Korea,124 China,125 Czech Republic,126,127 Hungary,128 Croatia,129 Uruguay,130 Romania,131,132 Brazil,133–136 Lebanon,137 States States,138 Lithuania,139 Turkey,140 Colombia,141 Norway142–144 and Poland,145 among the most important. IgA Nephropathy is the most frequent nephropathy in Europe and Asia, while in the USA the FSG could be increasing.42,73,74,146
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