Original articleBaseline Lamina Cribrosa Curvature and Subsequent Visual Field Progression Rate in Primary Open-Angle Glaucoma
Section snippets
Methods
This study was approved by the Seoul National University Hospital Institutional Review Board and adhered to the tenets of the Declaration of Helsinki. All participants provided written informed consent.
Results
Initially, 126 eyes meeting the eligibility criteria were enrolled. Among them, 18 were excluded because they had more than 4 OCT scans with poor image quality. Another 4 eyes were excluded because of associated retinal disease diagnosed over the course of the follow-up, and a further 3 eyes showing uncontrolled IOP also were excluded from the final analysis, leaving a final cohort of 101 eyes from 101 patients. Of 1212 scans from 101 eyes, 36 images were excluded because of poor image quality
Discussion
This study demonstrated the association of a greater baseline maLCCI with a significantly faster subsequent VF progression rate in POAG eyes. Additionally, we found a statistically significant maLCCI breakpoint above which there was a greater MD slope.
Both LCD and the LCCI have been used to evaluate the degree of LC posterior deformation as an indication of LC morphologic features. The LCD heretofore has been measured mostly from the reference plane BMO to the anterior LC surface.11, 13
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by Seoul National University Hospital Medical Research Collaborating Center, Seoul, Republic of Korea, for the statistical analysis.
HUMAN SUBJECTS: Human subjects or tissues were included in this study. Study protocol was approved by the institutional review board of the Seoul National University Hospital. This research adhered to the tenets of the Declaration of Helsinki. Informed consent was obtained from all human subjects.
No animal subjects were used in this study.
Author Contributions:
Conception and design: Ha, Y.K.Kim, Park, Jeoung
Analysis and interpretation: Ha, T.J.Kim, Girard, Mari, Park, Jeoung
Data collection: Ha, T.J.Kim, Girard, Mari, Park, Jeoung
Obtained funding: N/A
Overall responsibility: Ha, Y.K.Kim, Jeoung