Original articleImpact of the Introduction of Generic Latanoprost on Glaucoma Medication Adherence
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Data Source
The Clinformatics DataMart database (OptumInsight, Eden Prairie, MN) contains detailed de-identified records of all beneficiaries in a large nationwide managed care network. We had access to data for all beneficiaries with any form of eye care from January 1, 2001, through December 31, 2012. This subset comprises beneficiaries who had 1 or more International Classification of Diseases, Ninth Revision, Clinical Modification codes for any eye-related diagnosis (360–379.9); Current Procedural
Sociodemographic Characteristics of Eligible Enrollees
There were 8427 enrollees who met the study eligibility criteria (Fig 1). The mean ± standard deviation age of eligible enrollees was 66.1±12.1 years. There were 4424 females (52.5%), and the racial composition included 6288 white persons (74.6%), 1027 black persons (12.2%), 404 Latino persons (4.8%), 245 Asian persons (2.9%), and 66 persons of other races (0.8%). The sample included 8242 persons (97.8%) with at least a high school education and 1471 persons (17.5%) with an income of more than
Discussion
In this large nationwide sample of patients with OAG who were receiving treatment with PGAs, we identified a subset of patients who exhibited reduced medication adherence during the period when only brand-name PGAs were available. When this subset of patients was switched from the brand-name PGA to generic latanoprost, their adherence rose considerably, to levels higher than other patients who had been maintained on brand-name PGAs after generic latanoprost became available. After accounting
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Supplemental material is available at www.aaojournal.org.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported in part by the National Eye Institute, National Institutes of Health, Bethesda, Maryland (K23 Mentored Clinician Scientist Award no.: 1K23EY019511 to J.D.S.); and a Physician Scientist Award from Research to Prevent Blindness, Inc., New York, New York.