Original articleLaminar and Prelaminar Tissue Displacement During Intraocular Pressure Elevation in Glaucoma Patients and Healthy Controls
Section snippets
Participants
Open-angle glaucoma patients were recruited from the Eye Care Centre of the Queen Elizabeth Health Sciences Centre in Halifax, Nova Scotia. Age-matched and young healthy control subjects also were recruited. Controls were either spouses of patients or subjects who had previously taken part in research studies.
Inclusion criteria for patients were: (1) a clinical diagnosis of open-angle glaucoma with documented progressive optic disc change and visual field damage compatible with glaucoma and (2)
Results
Twelve patients with glaucoma and 24 healthy control subjects were tested. Subjects were divided into 3 groups of 12 subjects each: (1) glaucoma patients with average visual field mean deviation of −2.8 dB (range, −0.3 to −9.0 dB), (2) age-matched healthy controls, and (3) younger healthy controls. The demographic and ocular variables are shown in Table 1. Baseline IOP was significantly different among the groups (P = 0.011), with higher values in the glaucoma group compared with either control
Discussion
Considerable research in recent years has centered on the biomechanical changes in the optic nerve head, specifically in and around the lamina cribrosa, and how they may help explain the pathophysiology of glaucoma.10 Laminar stress and eventual deformation can have deleterious effects on axonal function via several mechanisms, including mechanical damage,3, 40, 41 compromised vascular supply,10 and increased translaminar pressure gradient.16, 42, 43, 44
Anterior displacement of the optic disc
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Manuscript no. 2009–1658.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
Balwantray C. Chauhan - Financial support - Heidelberg Engineering
Supported by grant MOP11357 from the Canadian Institutes of Health Research, Ottawa, ON, Canada (BCC); and a CNIB Baker Fellowship, Toronto, ON, Canada (YA).