Original articleDiurnal Intraocular Pressure Patterns are Not Repeatable in the Short Term in Healthy Individuals
Section snippets
Patients and Methods
This prospective study was reviewed and approved by the West Virginia University Institutional Review Board. The study was conducted in accordance with the tenets of the Declaration of Helsinki. All participating subjects provided written informed consent. Subjects were recruited between April 3, 2006, and April 16, 2007; the last subject exited the study on April 14, 2008. Participants were 18 years of age or older and were healthy. All subjects underwent a complete ophthalmologic examination
Results
Overall, 44 subjects without glaucoma were enrolled in this study, of whom 40 attended both visits 1 and 2 and were included in this analysis. All included subjects were white, 65% (26/40) were female, and the mean age±standard deviation was 66.5±12.9 years.
Mean IOP values by eye, time point, and visit are given in Table 1. Intraocular pressure values consistently were lower at visit 2 compared with visit 1, although the difference was not statistically significant at any time point in either
Discussion
These data show that individual eyes of healthy subjects do not follow a conserved IOP pattern from day to day. There was fair to good agreement for IOP at any given time on different days, but essentially no agreement for IOP change between time points on different days.
There are few data in the literature regarding the repeatability of IOP patterns in normal eyes over time. The evaluation by Daubs1 of a small group of airline pilots did not include a formal evaluation of IOP pattern
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Author reply
2015, Ophthalmology
Manuscript no. 2009-1295.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the National Eye Institute, Bethesda, Maryland (grant nos.: K23EY018859 and R03EY015682 [TR]); and by an unrestricted grant to West Virginia University from Research to Prevent Blindness, Inc., New York, New York.