Original ArticleCone- and Rod-Mediated Dark Adaptation Impairment in Age-Related Maculopathy
Section snippets
Materials and Methods
This study was approved by the institutional review board of the University of Alabama at Birmingham. Informed consent was obtained from all participants after the nature and possible consequences of the study were explained. Participants were recruited from the comprehensive ophthalmology and retina services of the Department of Ophthalmology, University of Alabama at Birmingham, based on clinic patients seen over a 14-month period in 2003 to 2004. Eligibility criteria were at least 50 years
Results
Table 1 provides demographic and VA information for participants. There were small differences in age among the 4 groups that were statistically significant (P = 0.0048), so comparisons of variables among groups were adjusted for age. There were slightly more females than males in most groups, and groups were predominantly white, of non-Hispanic origin. As expected, the old normal participants had the best VA, with increasingly worse VA with increased severity of ARM.
Table 2 displays dark
Discussion
When cone- and rod-mediated dark adaptation is measured in the parafovea in persons with early ARM, rod-mediated parameters, but not cone-mediated parameters, exhibit abnormalities. Increasingly severe ARM from early to advanced disease as defined by a standardized fundus grading scale was associated with greater impairment in rod-mediated dark adaptation. Specifically, with increased disease severity the time point at which rod photoreceptors emerged as more sensitive than cones (rod–cone
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2022, Ophthalmology ScienceThe role of dark adaptation in understanding early AMD
2022, Progress in Retinal and Eye ResearchCitation Excerpt :The idea behind the RIT was to concentrate exclusively on rod-mediated function and reduce the time for the testing. In Owsley et al. (2007), the AdaptDx was used to measure both rod and cone recovery function with a 1.7° circular test spot located at 12° in the inferior visual field. Cone function was measured with a 650 nm light and rod function with a 500 nm light.
Manuscript no. 2006-956.
Research supported by the National Institutes of Health, Bethesda, Maryland (grant nos. R01-AG04212, R21-EY14071); Research to Prevent Blindness, Inc., New York, New York; and EyeSight Foundation of Alabama, Birmingham, Alabama. Dr Owsley is a Research to Prevent Blindness Senior Scientific Investigator.
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Drs Owsley and Jackson are patent designees on a dark adaptation testing technology based on this and other work.