Neuron

Neuron

Volume 108, Issue 3, 11 November 2020, Pages 397-399
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Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement

https://doi.org/10.1016/j.neuron.2020.10.018Get rights and content
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Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs through the local binding of TWEAK to postsynaptic Fn14.

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