Combined effect of tumor necrosis factor (TNF)-α and heat shock protein (HSP)-70 in reducing apoptotic injury in hypoxia: A cell culture study
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Effect of desiccation on oxidative stress and antioxidant response of the black tiger shrimp Penaeus monodon
2016, Fish and Shellfish ImmunologyCitation Excerpt :HSP70 are ubiquitous and highly conserved stress proteins which play important roles in protecting organisms from the detrimental effects by stressors, such as heat or cold shock, hyperosmotic stress, reduced oxygen level and heavy metals, and has been proposed as the evaluation indexes of the environmental toxicants and stresses. In previous studies, HSP70 have been identified to induce by hypoxia stress [39–42]. Ferritin is known to play important roles in the regulation of iron metabolic balance, detoxification and anti-oxidation [43], which can inhibit the formation of ROS by restricting excess free iron to inhibit the Fenton reaction, thereby reducing the production of ·OH [25].
Comparative proteomic study of the response to hypoxia in the muscle of oriental river prawn (Macrobrachium nipponense)
2016, Journal of ProteomicsCitation Excerpt :Under stress conditions, heat shock proteins (HSPs) act as molecular chaperones to regulate protein homeostasis, prevent aggregation and assist refolding of misfolded proteins. Up-regulation of HSP70 following hypoxia has been reported previously in mammals [36]. Given the known functions of HSP70, up-regulation in the muscle of hypoxia treated prawns may be associated with the increased production of ROS.
Quantification of heat shock protein mRNA expression in warm and cold anoxic turtles (Trachemys scripta) using an external RNA control for normalization
2012, Comparative Biochemistry and Physiology - Part D: Genomics and ProteomicsCitation Excerpt :In particular, in mammals, HSPs serve a number of cytoprotective functions, including assisting in the folding or refolding of proteins and the targeting of irreparable polypeptides for degradation (Lindquist and Craig, 1988). Indeed, HSP expression is induced in cardiac and central nervous tissue of anoxia-sensitive species in response to hypoxia and ischemia/reperfusion (e.g., Kawana et al., 2000; Goel et al., 2010). Similarly, HSPs are likely to promote anoxia survival in the turtle and crucian carp.
Environmental hypoxia induces apoptosis in large yellow croaker Larimichthys crocea via both intrinsic and extrinsic pathways
2023, Journal of Oceanology and LimnologyHsp70 in cancer: A double agent in the battle between survival and death
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