Weakened long-range correlation of renal sympathetic nerve activity in Wistar rats after anaesthesia

doi:10.1016/j.neulet.2007.12.038

Neuroscience Letters

Volume 433, Issue 1, 5 March 2008, Pages 28-32

https://doi.org/10.1016/j.neulet.2007.12.038 Get rights and content

Abstract

In this study we employed multiscale entropy (MSE) measurement to assess the long-range temporal correlation (LRTC) of multifibre renal sympathetic nerve activity (RSNA) signals in conscious and anaesthetized Wistar rats. It was found that both groups presented more complex MSE profiles than an uncorrelated process. Moreover, the results of MSE analysis of RSNA demonstrated that the entropy values, derived from the conscious group, increased on small time scales and then stabilized to a relatively constant value, however, the entropy measure, derived from animals with anaesthesia, almost monotonically decreased. The present study shows that while LRTC in the temporal dynamics of energy fluctuations of RSNA does not implicate a unique mechanism, the data for the first time provide evidence of much less temporal correlation in anaesthetized condition. This suggests the fractal properties of underlying dynamical system have been effectively eliminated by anaesthesia. These results demonstrate that apparently random fluctuations in multifibre RSNA are dictated by a complex deterministic process that imparts “long-term” memory to the dynamic system. However, this memory is significantly weakened by anaesthesia.

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Acknowledgements

This work was supported by grants from the NBRPC (2007CB914803) and the NSFC (30470453, 30640037). We are grateful to Professor Johns EJ (Department of Physiology, University College of Cork, Ireland), who kindly provided the data of conscious rats.

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Furthermore, the action of urethane affects particularly the intrinsic membrane properties of rat visual cortical neurons [38]. Our previous studies have shown that the long-range temporal correlation of renal sympathetic nerve activity (RSNA) was significantly weakened by urethane-anesthesia in anesthetized Wistar rats compared to that in conscious Wistar rats [22,23]. The hippocampus has been widely used for studies of anesthetics [33] and appears to be an important locus for anesthetic action [25].
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Weakened long-range correlation of renal sympathetic nerve activity in Wistar rats after anaesthesia

Abstract

Section snippets

Acknowledgements

Neuroscience

Biol. Psychol.

Prog. Neurobiol.

J. Auton. Nerv. Syst.

Neuroscience

Phys. A

Self-organized criticality

Phys. Rev. A

Multiscale entropy analysis of biological signals

Phys. Rev. E

Multiscale entropy analysis of complex physiologic time series

Phys. Rev. Lett.

Fractal properties of sympathetic nerve discharge

J. Neurophysiol.