Elsevier

Neuroscience Letters

Volume 407, Issue 1, 16 October 2006, Pages 6-10
Neuroscience Letters

APP23 mice display working memory impairment in the plus-shaped water maze

https://doi.org/10.1016/j.neulet.2006.07.060Get rights and content

Abstract

Alzheimer's disease (AD) patients typically present short-term memory deficits, before long-term memory capacity declines with disease progression. Several studies have described learning and memory deficits in the APP23 mouse model. Our group reported a decline of learning and memory capacities from the age of 3 months onwards using a hidden-platform Morris water maze (MWM). The aim of the present study was to evaluate working and reference memory in APP23 mice in the same plus-shaped water maze. The transgenic mice had slower learning curves; however, consolidation of the learned information appeared intact in this learning paradigm. This report demonstrates impairment of working memory in this transgenic Alzheimer model.

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Acknowledgments

This work was financed by the Fund for Scientific Research—Flanders (FWO, grant G.0038.05), agreement between Institute Born-Bunge and the University of Antwerp, the Medical Research Foundation Antwerp, Neurosearch Antwerp, and the Thomas Riellaerts Research Fund. D.V.D. holds a postdoctoral position at the University of Antwerp.

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    Present address: Laboratory of Biological Psychology, University of Leuven, Tiensestraat 102, B-3000 Leuven, Belgium.

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