Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease
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Acknowledgement
This study was supported by the National Institutes on Aging grants AG 13672 and AG 05133.
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Cited by (14)
Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome
2015, Neurobiology of AgingCitation Excerpt :However, data on the relation of the IDE locus with AD are conflicting. Some studies showed no association between the IDE locus and LOAD (Abraham et al., 2001; Boussaha et al., 2002; Nowotny et al., 2005; Ozturk et al., 2006; Sakai et al., 2004), whereas other studies have found an association (Carrasquillo et al., 2010; Vepsalainen et al., 2007; Zuo and Jia, 2009). SORCS1 is a member of the vacuolar protein sorting 10 (VPS10) domain-containing receptor protein family.
Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease
2013, Neuroscience LettersCitation Excerpt :In all studies, the control genotype distributions were in Hard–Weinberg equilibrium (HWE). Through the literature search and selection based on the inclusion criteria, six case–control studies of the association between the rs1832196 polymorphism and AD were also included in our meta-analysis [3,9,16,19,21,22]. Our final eligible studies included six studies with 4374 cases and 3949 controls (Table 1).
The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population
2012, Journal of Clinical NeuroscienceCitation Excerpt :Several studies of the relationship between IDE and AD using a single nucleotide polymorphism (SNP) approach have indicated that some variations were related to LOAD.12–16 However, the results of these genetic studies remain controversial, with some studies unable to identify any association with AD.17–19 In the present study, we genotyped two SNP (rs4646958 and rs1887922), which have been reported to be associated with an increased risk of AD in the Caucasian population.
Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease
2009, Ageing Research ReviewsCitation Excerpt :Data regarding IDE gene in SAD case–control association studies were summarized in Table 1. Among the nine studies on Caucasian population (Abraham et al., 2001; Boussaha et al., 2002; Prince et al., 2003; Ertekin-Taner et al., 2004; Nowotny et al., 2005; Mueller et al., 2007; Björk et al., 2007; Ozturk et al., 2006; Liang et al., 2007), five articles did not find any association beween IDE polymorphisms and SAD (Abraham et al., 2001; Boussaha et al., 2002; Nowotny et al., 2005; Ozturk et al., 2006; Liang et al., 2007). Abraham et al. (2001) reported that IDE did not make a substantial contribution to SAD, and therefore could not account for the described linkage between SAD and chromosome 10q.
Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease
2006, Neuroscience Letters
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Current address: Department of Periodontology, School of Dental Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.