A single evoked afterdischarge produces rapid time-dependent changes in connexin36 protein expression in adult rat dorsal hippocampus
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Acknowledgements
We thank Dr. Joseph Cheer and Dr. John Simeral for helpful discussion and technical advice. This study was supported by NIH P50DA06643.
References (40)
- et al.
Electrical coupling and neuronal synchronization in the Mammalian brain
Neuron
(2004) - et al.
Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures
Mol. Cell Neurosci.
(2002) - et al.
Downregulation of connexin 43 gene expression in rat heart during inflammation. The role of tumour necrosis factor
Cytokine
(1999) - et al.
Stimulus complexity dependent memory impairment and changes in motor performance after deletion of the neuronal gap junction protein connexin36 in mice
Behav. Brain. Res.
(2005) - et al.
Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)
Neuropharmacology
(2004) - et al.
Upregulation of gap junction connexin 32 with epileptiform activity in the isolated mouse hippocampus
Neuroscience
(2001) - et al.
The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine
Behav. Brain. Res.
(2004) - et al.
Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice
Neuroscience
(2003) - et al.
Regulation of connexin degradation as a mechanism to increase gap junction assembly and function
J. Biol. Chem.
(2000) - et al.
Prolonged decrease in hepatic connexin32 in chronic liver injury induced by carbon tetrachloride in rats
J. Hepatol.
(1996)
Gap junctions, synchrony and seizures
Trends Neurosci.
Modification of seizure activity by electrical stimulation. I. After-discharge threshold
Electroencephalogr. Clin. Neurophysiol.
Modification of seizure activity by electrical stimulation. II. Motor seizure
Electroencephalogr. Clin. Neurophysiol.
Expression of connexin genes in hippocampus of kainate-treated and kindled rats under conditions of experimental epilepsy
Brain Res. Mol. Brain Res.
Involvement of electrical coupling in the in vivo ictal epileptiform activity induced by 4-aminopyridine in the neocortex
Neuroscience
Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists
Neuropharmacology
Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo
J. Neurosci.
Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells
Eur. J. Neurosci.
Electrical synapses in the mammalian brain
Annu. Rev. Neurosci.
Five-hour half-life of mouse liver gap-junction protein
J. Cell Biol.
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Contribution of non-selective membrane channels and receptors in epilepsy
2022, Pharmacology and TherapeuticsCitation Excerpt :Increases have been reported in mRNA and protein amounts of Cx36 24 h after kindling (Beheshti et al., 2010) and 3–6 h after kainate-induced seizures (Wu, Wang, Hao, & Feng, 2017), but they returned to basal or even decreased levels, respectively. Otherwise, there is more evidence of a down-regulation in Cx36 mRNA and protein levels (McCracken & Roberts, 2006; Wu et al., 2018; Zappalà et al., 2006). Actually, in the study of Wu and collaborators (2018), a significant decrease of Cx36 levels was found in the CA1, CA3 and Dentate Gyrus (DG) of the hippocampus of a pilocarpine-induced SE model, which corresponds to a decrease of Cx36 in GABAergic interneurons, suggesting a less effective inhibitory control of excitatory runaway activity (Trevelyan, Sussillo, Watson, & Yuste, 2006).
Cx36 in the mouse hippocampus during and after pilocarpine-induced status epilepticus
2018, Epilepsy ResearchCitation Excerpt :Increase of Cx36 mRNA and protein levels occurred at 24 h after the kindling (Beheshti et al., 2010). Down regulation of Cx36 expression in the hippocampus was observed at 2 h, 4 h and 8 h after injection of 4-aminopyridine (Zappala et al., 2006), at 3 h following an electrically stimulated afterdischarge (McCracken and Roberts, 2006), and from 6 h to 48 h after kainate treatment (Condorelli et al., 2003). In the present study, in the pilocarpine model of temporal lobe epilepsy, a significantly decreased expression of Cx36 mRNA and protein was observed at 1 h and 4 h during and 1 week after status epilepticus.
Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation
2017, Behavioural Brain ResearchCitation Excerpt :Although connexins are membrane proteins, it was indicated that their expression levels could change rapidly. A single evoked after-discharge produced a rapid (3 h post-stimulation), time-dependent decrease in Cx36 protein expression in adult rat dorsal hippocampus [52]. Hence, we studied the time profile of Cx36 and Cx45 mRNA expression levels from an early time point of 30 min–24 h.
Changes in hippocampal connexin 36 mRNA and protein levels during epileptogenesis in the kindling model of epilepsy
2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Present address: Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.