Expression profiles of genes in DJ-1-knockdown and L166P DJ-1 mutant cells
Section snippets
Acknowledgments
We thank Yoko Misawa and Kiyomi Takaya for their technical assistance. This work was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and the Ministry of Health, Labor and Welfare of Japan.
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Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1
2020, Redox BiologyCitation Excerpt :Indeed, a recent study reported on DJ-1 regulation of flotilin-1 and caveolin-1 stability with resulting alterations in cellular cholesterol level, membrane fluidity, and lipid raft-dependent endocytosis of astrocytes [42]. In addition, a different study reported that low-density lipoprotein receptor (LDLR) gene expression is altered in DJ-1 KO cells [43]. The same group subsequently reported that DJ-1 stimulates LDLR gene expression at the transcriptional level by associating with SREBP and affects serum LDL cholesterol levels in male mice [44].
Expression of DJ-1 proteins in placentas from women with severe preeclampsia
2013, European Journal of Obstetrics and Gynecology and Reproductive BiologyInvolvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders
2012, Free Radical Biology and MedicineNuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
2012, Free Radical Biology and MedicineCitation Excerpt :Indeed, it has been shown that DJ-1 seems to exert its antioxidative effects by directly regulating gene expression. For example, previous studies showed that during oxidative stress, DJ-1 may modulate the expression of genes such as glutamate–cysteine ligase, the rate-limiting enzyme of glutathione biosynthesis; extracellular superoxide dismutase (SOD3) [16,17]; or manganese superoxide dismutase (MnSOD) synergistic with peroxisome proliferator-activated receptor γ coactivator 1α [18]. DJ-1 can also modulate expression of several other genes including androgen receptor reporter activity by interacting with PIASx, which is known as androgen receptor-interacting protein-3 [19,20], as well as tyrosine hydroxylase [21] and Bax [22].
Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death
2012, Biochemical and Biophysical Research CommunicationsCitation Excerpt :DJ-1 has also been suggested to play an active role as a neuroprotective transcriptional co-activator [9]. During oxidative stress, DJ-1 has been demonstrated to modulate the expression of genes such as glutamate cysteine ligase, extracellular superoxide dismutase (SOD3), or MnSOD [10–12]. DJ-1 also represses Bax expression through p53 interaction and exerts cytoprotection against Bax-induced, caspase-dependent cell death [13].
Down-regulation of DJ-1 protein in the ejaculated spermatozoa from Chinese asthenozoospermia patients
2011, Fertility and SterilityCitation Excerpt :We also found that SOD activity was positively correlated with sperm DJ-1 concentration. Nishinaga et al. (27) reported that expression of the extracellular superoxide dismutase (SOD3) gene was decreased in DJ-1–knockdown cells, suggesting that the gene expression of SOD3 is regulated by DJ-1. Taken together, the decrease in sperm DJ-1 levels may lead to down-regulation of SOD, which would contribute to oxidative stress and reduce sperm motility.