Elsevier

Materials Science and Engineering: C

Volume 92, 1 November 2018, Pages 1041-1060
Materials Science and Engineering: C

Review
Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics

https://doi.org/10.1016/j.msec.2017.12.036Get rights and content

Highlights

  • Recent advances in development of PLGA based particle system for the delivery of biomacromolecular therapeutics was reviewed.

  • Current methods for the preparation of PLGA based MPs/NPs were introduced.

  • Strategies for the loading of PLGA based MPs/NPs with biomolecular therapeutics were introduced.

  • Conditions influencing the release of biomacromolecules from PLGA based particles were discussed.

  • Recent examples of PLGA based MPs/NPs as vehicles for the delivery of biomacromolecular drugs were highlighted and reviewed.

Abstract

Recent advancements in biopharmaceutical industry have facilitated the development of novel bioactive macromolecular therapeutics. One of the challenges towards the clinical use of these biomacromolecules lies in the selection of appropriate carriers to protect, deliver and release them in vivo to maximize their pharmacological effects. Micro/nanoparticles made from biodegradable poly (d,l-lactic-co-glycolic acid) (PLGA) have been explored as delivery vehicles for therapeutics. Due to their excellent biocompatibility and controllable biodegradability, PLGA micro/nanoparticles could protect macromolecules from instant degradation in vivo while allowing tunable release rate and profile. In this review, recent progress in the design, fabrication/formulation and application of PLGA based micro/nanoparticles for the controlled delivery of biomacromolecules are discussed. Special focuses will be on the novel loading methods and releasing mechanisms of macromolecules as well as the in vivo applications of therapeutic macromolecule-loaded PLGA micro/nanoparticles.

Keywords

PLGA
Drug delivery
Protein and nucleic acid
Controlled and stimuli-responsive release

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