Long-term and controlled release of chlorhexidine–copper(II) from organically modified montmorillonite (OMMT) nanocomposites
Graphical abstract
The antibacterial agent of chlorhexidine was first complexed with copper(II) chloride and then intercalated into the interlayer of MMT to form nanocomposites. The CHX–Cu/MMT composites exhibited long-term antibacterial activity and controlled release behaviors.
Highlights
► Chlorhexidine–copper (II)/montmorillonite (CHX–Cu/MMT) complex exhibits improved antimicrobial activity. ► Intercalating chlorhexidine–copper (II) complex into the interlayer of clay endows a long-term and controlled-release. ► Release kinetics indicated that the release process satisfied a pseudo-second-order mode. ► A nearly lateral-monolayer arrangement of CHX–Cu was supposed for the intercalation.
Keywords
Antibacterial activity
Controlled release
Chlorhexidine diacetate
Montmorillonite
Nanocomposites
Cited by (0)
Crown copyright © 2012 Published by Elsevier B.V. All rights reserved.