Spotlight
A lncRNA Decoy Predicts Sensitivity to Cisplatin

https://doi.org/10.1016/j.molmed.2020.01.015Get rights and content

In a recent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA–RNA triplex and to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as a treatment efficacy biomarker. This opens promising avenues of research from both mechanistic and translational perspectives.

Section snippets

Acknowledgments

We thank the CERCA Programme/Generalitat de Catalunya and the Josep Carreras Foundation for institutional support.

Cited by (8)

View all citing articles on Scopus
@

Twitter: @GroupGuil (S. Guil)

View full text