Molecular Cell
Volume 82, Issue 12, 16 June 2022, Pages 2188-2189
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TADs do not stay in the loop

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In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a “partially extruded state” and that CTCF-CTCF loops are rare.

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