Molecular Cell
Volume 59, Issue 4, 20 August 2015, Pages 515-516
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Shockingly Early: Chromatin-Mediated Loss of the Heat Shock Response

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In this issue of Molecular Cell, Labbadia and Morimoto (2015) show that there is a precipitous decline in stress resistance at the onset of reproduction in C. elegans and that this transition is regulated by changes in repressive chromatin marks.

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