Elsevier

Microbes and Infection

Volume 15, Issues 10–11, September–October 2013, Pages 745-748
Microbes and Infection

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Temporal variation of Trypanosoma cruzi discrete typing units in asymptomatic Chagas disease patients

https://doi.org/10.1016/j.micinf.2013.06.008Get rights and content
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Abstract

Chagas disease caused by Trypanosoma cruzi is a public health problem in Latin America. This parasite displays a high genetic diversity evidenced in six Discrete Typing Units (DTUs) namely TcI–TcVI. The aim of this study was to observe the temporal variation of the DTUs in asymptomatic patients at three different times (10 days interval). The results showed that intermittence is the rule in the bloodstream of Chagas disease patients. The patients showed different detectable DTUs with short time intervals, which favors the clonal histiotropic model and the multiclonality structure of this parasite.

Keywords

Discrete typing unit
Multiclonality
Chagas disease
Temporal distribution
SL-IR

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