Elsevier

Microbes and Infection

Volume 13, Issue 4, April 2011, Pages 312-321
Microbes and Infection

Review
Japanese encephalitis virus: from genome to infectome

https://doi.org/10.1016/j.micinf.2011.01.002Get rights and content
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Abstract

Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection.

Keywords

Japanese encephalitis
Neurotropic infection
Neuropathogenesis
Mosquito borne infections
Arboviral infections

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