Tenascin-C increases lung metastasis by impacting blood vessel invasions
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open access
Abbreviations
BVI
blood vessel invasions
CD31
cluster of differentiation 31
CD41
cluster of differentiation 41, integrin alpha chain 2b
Cl. Cas-3
cleaved caspase-3
CK8/18
cytokeratin 8/18
DAPI
4′,6-diamidino-2-phenylindole
DMEM
Dulbecco's Modified Eagle's Medium
ELISA
Enzyme-linked immunosorbent assay
EPC
endothelial progenitor cells
EMT
epithelial-to-mesenchymal transition
ERK
extracellular signal-regulated kinases
ECM
extracellular matrix
FN
fibronectin
Fsp1
fibroblast-specific protein 1
GAPDH
Glyceraldehyde 3-phosphate dehydrogenase
GW788388
4-(4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl)-N-(tetrahydro-2Hpyran-4-yl) benzamide
HCC
hepatocellular carcinoma
HE
Hematoxylin and eosin
IDC NST
invasive ductal carcinoma, no special type
KD
knock down
KO
knock out
LM
laminin
LVI
lymph vessel invasions
MaCa
mammary carcinomas
Mmp9
Matrix metallopeptidase 9
MMTV-NeuNT
mouse mammary tumor virus driven NeuNT (activated rat ErbB2 homologue) transformed
NOS
not otherwise specified
NT193
MMTV-NeuNT breast tumor derived cell line
Pai-1
plasminogen activator inhibitor-1
PBS
phosphate-buffered saline
PDAC
pancreatic ductal adenocarcinomas
PNET
pancreatic neuroendocrine tumors
PyMT
polyoma middle T antigen
RAM1
reduced Arbuscular Mycorrhization 1
RCC
renal cell carcinoma
Sh
short hairpin
Slug
snail family zinc finger 2
Snail
snail family zinc finger 1
STS
staurosporine
TGF-β
transforming growth factor β
TME
tumor microenvironment
TNBC
triple negative breast cancer
TNC
tenascin-C
VEGFA
vascular endothelial growth factor A
WT
wild type
Zeb1
zinc finger E-box-binding homeobox 1
α-SMA
alpha-smooth muscle actin
Keywords
Blood vessel invasions
Circulating tumor cells
Tumor emboli
Tenascin-C
Cellular plasticity
TGF-β signaling
Lung metastasis
Endothelialization
Fsp1+ cells
Endothelial cells
Cited by (0)
- 1
Current address: 1. Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China. 2. Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China.
- 2
Equal contribution.
© 2019 The Authors. Published by Elsevier B.V.