Clinical StudyDual-Port versus Mono-Port Implantation for Intra-Arterial Chemoinfusion Therapy for Treatment of Hepatocellular Carcinoma in Patients with Anatomic Hepatic Artery Variation
Section snippets
Materials and Methods
The institutional review board of our institution approved the study design and waived the requirement for informed consent based on the study’s retrospective design. Between July 2011 and November 2016, a total of 232 HCC patients underwent percutaneous placement of hepatic arterial-port catheter systems at our interventional unit. The patients were refractory to previous treatment or not amenable to locoregional therapies, such as ethanol injection, radiofrequency ablation, or transcatheter
Results
Of a total of 22 patients, 12 patients underwent mono-port systems, and 10 patients underwent dual-port systems. The patients received a total of 60 cycles of HAIC, with a median of 2 cycles (range, 1–7 cycles). The most common cause of underlying liver disease was hepatitis B (72.7%). All patients were Barcelona Clinic Liver Cancer stage C and had PVTT involving lobar (n = 16) or bilobar (n = 6) portal veins. The most common hepatic arterial variation was replaced right hepatic artery arising
Discussion
Maintaining homogeneous distribution of anticancer drugs throughout the entire tumor-bearing region in the liver is important to accomplish HAIC efficiently (12). For the homogeneous distribution of anticancer drugs, only 1 implanted catheter is recommended in patients with conventional anatomy of the celiac and superior mesenteric arteries. In patients with accessory or replaced hepatic arteries, embolization of aberrant arteries is required for redistribution of the hepatic arterial perfusion
References (19)
- et al.
Implantation of a port-catheter system through the superior mesenteric artery for repeated hepatic arterial infusion chemotherapy
J Vasc Interv Radiol
(2007) - et al.
Influence of extrahepatic arterial inflow into the posterior segment or caudate lobe of the liver on repeated hepatic arterial infusion chemotherapy
J Vasc Interv Radiol
(2005) - et al.
Survival benefits of intra-arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis
Hepatol Res
(2005) - et al.
Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: a comprehensive review
World J Gastroenterol
(2016) - et al.
Transarterial radioembolization for hepatocellular carcinoma: an update and perspectives
World J Gastroenterol
(2015) - et al.
Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis
World J Gastroenterol
(2013) - et al.
Redistribution of multiple hepatic arteries into a single hepatic artery to perform repeated hepatic arterial infusion chemotherapy
Acta Radiol
(2008) - Arai Y, Inaba Y, Takeuchi Y. Interventional techniques for hepatic arterial infusion chemotherapy. In: Castaneda-Zuniga...
- et al.
Evaluation of intrahepatic perfusion on fusion imaging using a combined CT/SPECT system: influence of anatomic variations on hemodynamic modification before installation of implantable port systems for hepatic arterial infusion chemotherapy
Cardiovasc Intervent Radiol
(2007)
Cited by (0)
None of the authors have identified a conflict of interest.