Laboratory InvestigationEffect of Transcatheter Intra-Arterial Therapies on Tumor Interstitial Fluid Pressure and Its Relation to Drug Penetration in a Rabbit Liver Tumor Model
Section snippets
Animal Model, Magnetic Resonance Imaging, and Study Groups
The present study was approved by the animal care and use committee of our institution. Adult New Zealand White rabbits (body weight, 2.5–3.0 kg) were purchased from the Center for Experimental Animals of Huazhong University of Science and Technology. The strain of VX2 tumor was maintained by successive implantation into the thigh of carrier rabbits. Tumor implantation was performed by using an aseptic technique, and general anesthesia was introduced with intravenous (IV) sodium pentobarbital
Results
The pretreatment mean tumor sizes are shown in Table 1. There were no significant differences between groups in tumor largest diameter (P = .978) and tumor volume (P = .994).
In all 16 rabbits, the pretreatment IFP in the tumor center was significantly higher than in the adjacent normal liver tissue (27.3 mm Hg ± 6.1 and 12.7 mm Hg ± 5.7, respectively; P < .001). Table 2 and Figure 2 summarize the pre- and postprocedural tumor IFPs and the IFP percentage change in the four groups at 1 hour after
Discussion
Drug penetration in tumor is a complex and dynamic process, and many factors that affect drug penetration may affect the final efficacy of chemotherapy (6, 9). Although systemic chemotherapy is ineffective for liver cancer, improved efficacy of transcatheter techniques with chemotherapy have shed new light on the implications of chemotherapy for this tumor. A previous study showed that embolization improved drug penetration in liver cancer (4), but the mechanism has not been adequately studied.
Acknowledgment
This research was supported by National Natural Sciences Foundation of China Grants 81101134 and 81471765.
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None of the authors have identified a conflict of interest.