Clinical studyPersonalized prediction of chronic wound healing: An exponential mixed effects model using stereophotogrammetric measurement
Introduction
The chronic wound that fails to heal presents a significant burden for both the affected individual and for all those who care for them, from the caregiver to the healthcare system. The goal of clinical management is to promote healing, yet the progress can be slow and intermittent. This makes it very difficult for even the expert wound care practitioner to predict time to healing. This is disheartening not just for the patient but also for the clinician who may feel a need to change therapeutic interventions if healing rates do not appear to improve. Healthcare systems also have to plan care for patients requiring indefinite periods of management.
The multi-stage pathway for acute wound healing is well known, comprising three main phases: 1) Initial haemostatis followed by inflammation, 2) proliferation and closure and 3) maturation and remodeling [1]. The healing process in biological systems has been modeled using a Gompertz-like function to follow an exponential course [2]. This presumes that the rate of change of wound size progressively decreases as the residual wound area approaches total closure. The final closure is very slow, with minute changes in wound size changes occurring over long periods of time.
When considering the chronic wound in the clinical setting, the normal pathway is disrupted and these models do not fit reliably. A major challenge with implementing models based on clinical measurement data is that wound measurement has traditionally been highly unreliable, almost subjective. [3] Accurate wound measurement is essential to provide clinically valid measures. Changes in wound geometry indicate whether a wound is getting smaller, i.e. healing, static or increasing in size. Recent developments in stereophotogrammetric digital imaging have provided readily available technology that can rapidly and accurately obtain a detailed 3D wound image at the bedside. Extensive validation of the LifeViz system using both a static imaging phantom and a dynamic imaging phantom adjustable for different volume quantities has shown the system provides a precise objective dimensional images [4]. We have previously shown that this approach has utility and good inter-observer reliability in the clinical in-patient setting [5].
In the current study we explored the feasibility of applying this rich data source to the development of individualized predictive curves using a statistically validated mixed-effects exponential model to provide predictive information on the healing pathway for chronic wounds.
Section snippets
Study protocol
Wound images were obtained from a sample of 13 category III/IV pressure ulcers (PUs) from 10 individuals with spinal cord injury (SCI), three patients in the study cohort had two PUs. Primary inclusion criteria were that patients were ≥18 years of age, but were not scheduled for surgical wound closure or sharp debridement. The LifeViz 3D system (Quantificare Inc.) was used to obtain wound images weekly over a consecutive 6-week period. The data collection methodology is described in detail in
Predictive model development
A total of 147 valid images were obtained for model development using DermaPix output variables to determine wound geometric properties over time.
Exploratory data analysis (EDA) was first applied to the raw data. The results demonstrated that more severe wounds had steeper healing trajectories than smaller wounds. Six of 13 wounds showed a slightly deteriorating trend for all wound geometry variables in the first one to two weeks before showing steady improvements. This suggests a two-phase
Discussion
We have previously shown that advanced wound assessment using stereophotogrammetric imaging has the potential to provide the clinician with an accurate representation of the wound at the time of assessment. Our preliminary model development now shows that accurate wound geometric data can also be used to predict the wound healing pathway on a personalized iterative basis.
Most current wound healing models utilize complete wound closure as the endpoint and apply analysis similar to survival
Conclusion
Preliminary results suggest that the routine assessment of wounds using detailed stereophotogrammetric imaging has the potential to provide personalized predictive indications of wound healing. The proposed mixed effect exponential model compares well with the existing models. Application of a valid predictive wound healing model will help the clinical team to determine treatment plan efficacy, selection of advanced wound therapeutics and even discharge planning.
Conflict of interest
The authors have no commercial relationships which may lead to a conflict of interests with regard to the information presented in this paper.
Acknowledgments
The authors wish to acknowledge the support of personnel and veterans at the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio. These individuals provided invaluable assistance in obtaining and analyzing the images used in developing the predictive model.
References (11)
- et al.
Wound healing primer
Surg Clin North Am
(2010 Dec) - et al.
Statistical analysis of wound-healing rates for pressure ulcers
Am J Surg
(2004 Jul) - et al.
A systematic review of the performance of instruments designed to measure the dimensions of pressure ulcers
Wound Repair Regen
(2012 May–Jun) - et al.
Quantification of skin lesions with a 3D stereovision camera system: validation and clinical applications
Skin Res Technol
(2013 Feb) - et al.
Repeatability and clinical utility in stereophotogrammetric measurements of wounds
J Wound Care
(2013 Feb)
Cited by (14)
Development and use of a porcine model with clinically relevant chronic infected wounds
2023, Journal of Tissue ViabilitySmart technologies in wound prevention and care
2019, Innovations and Emerging Technologies in Wound CareEvaluating accuracy and reliability of active stereophotogrammetry using MAVIS III Wound Camera for three-dimensional assessment of hypertrophic scars
2017, BurnsCitation Excerpt :An ideal measurement tool for assessing hypertrophic burn scars would be one that is valid, reliable, sensitive to change over time, and is capable of determining scar characteristics such as its volume, area, pigmentation, and circumference. The principle of stereo-photogrammetry to generate 3-D reconstructions of scar tissue, and subsequently, determine its volume, has recently gained considerable attention [10,15–17,22]. Stereophotogrammetry works by capturing two images of a target object from different angles [10].
Degradation science: Mesoscopic evolution and temporal analytics of photovoltaic energy materials
2015, Current Opinion in Solid State and Materials ScienceCitation Excerpt :These measures are also analogous to descriptors used in image analyses. Individualized longitudinal predictive models that can be updated over time [142] will be extremely important for critical system monitoring. The software packages for effective change point analyses that are applicable to degradation science and monitor system transitions are needed [143,144].
Smart and versatile biomaterials for cutaneous wound healing
2023, Biomaterials ResearchIntegrating adjunctive therapy into practice:recognising ‘hard-to-heal’ wounds
2021, Journal of Community Nursing