Original ArticleNascent Deep Microbleeds and Stroke Recurrences
Section snippets
Subjects
Between April 2004 and October 2009, we enrolled patients who were consecutively admitted to our hospital within 7 days of experiencing a stroke (index stroke). Follow-up took place until January 2010 at the latest, and stroke recurrences were evaluated in all patients. For patients with long follow-up periods, repeat MRI scans were performed around 1 year after the index strokes and were compared to the initial MRI scan obtained at admission to identify any nascent MBs and any asymptomatic
Results
Of the 1095 patients consecutively enrolled during the study period, we obtained repeated T2∗-weighted MRI scans from 508 patients (207 women, 68.9 ± 11.5 years of age) with a modified Rankin Scale score ≤ 3. The mean follow-up period was 44.1 ± 15.4 months. The types and frequencies of index strokes at admission were as follows: ICHs in 114 patients (28 lobar and 86 deep ICHs), lacunar infarctions in 149, atherothrombotic infarctions in 125, cardioembolic infarctions in 65, infarctions of
Discussion
We hypothesized that nascent MBs might be directly associated with the current degree of cerebral microangiopathy. We prospectively examined nascent deep MBs as a potential clinical risk factor in patients with strokes.
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2022, Revue de Medecine InterneAssociation of Ultrasonography and MRI Findings with Stroke Recurrence: Differences Between Patients with Past Histories of Atherothrombotic Versus Lacunar Infarctions
2019, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Lobar areas included subcortical and cortical areas. MRI parameters were described in previous manuscripts.2,3 To clarify the contribution of MBs to stroke recurrence, we divided MBs into 3 groups: strictly deep MBs, strictly lobar MBs, and mixed MBs (coexistence of deep and lobar MBs) and compared to the group without MB.
Volumetric Analysis of Carotid Plaque Components and Cerebral Microbleeds: A Correlative Study
2017, Journal of Stroke and Cerebrovascular DiseasesPredictors of New Cerebral Microbleeds in Patients with Antiplatelet Drug Therapy
2016, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :However, several studies have shown a higher prevalence and number of CMB in patients taking antiplatelet drug therapy as compared to nonusers,5,7,10 and a higher risk and mortality of intracerebral hemorrhage in these patients.9,11,12 Furthermore, previous studies also revealed an association between the development of new deep microbleeds after a first stroke and overall stroke recurrence and deep intracerebral hemorrhage, even after adjusting for pre-existing microbleeds and other risk factors.7,13 Therefore, clinicians need to weigh the risk associated with the development of new microbleeds against the benefits of antiplatelet drug therapy.
Contribution of Deep Microbleeds to Stroke Recurrence: Differences between Patients with Past Deep Intracerebral Hemorrhages and Lacunar Infarctions
2015, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :WML is reported to be originated from the chronic ischemia related to severe microangiopathy.26,27 Several studies have demonstrated that both deep and lobar MBs strongly correlated with severe WML.11,12,23,24 If severe WML was a stronger variable than deep MBs, deep MBs might fail to be associated with deep ICHs or LIs presenting as stroke recurrences in multivariate analyses.