Full paperAlendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts
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Keywords
Alendronate
Collagen I
Geranylgeranylation
RhoA
Rho kinase
Abbreviations
ALN
alendronate
Ang II
angiotensin II
ANOVA
a one-way analysis of variance
CF
cardiac fibroblast
DMAPP
dimethylallyl pyrophosphate
DMEM
Dulbecco's modified Eagle's medium
ECM
extracellular matrix
ELISA
enzyme immunoassay
FBS
fetal bovine serum
FOH
farnesol
FPP
farnesylpyrophosphate
FPPS
farnesylpyrophosphate synthase
GGOH
geranylgeraniol
GGPP
geranylgeranyl pyrophosphate
GGPPS
geranylgeranyl pyrophosphate synthase
GPP
geranyl pyrophosphate
GGTase I
geranylgeranyl pyrophosphate type I
qRT-PCR
quantitative real-time polymerase chain reaction
ROCK
Rho kinase
SD
standard error
SFM
serum-free medium
TGF-β1
transforming growth factor-β1
TNF-α
tumor necrosis factor-α
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