Original articleInsulin Resistance in Adolescents
Section snippets
Study Population
Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were analyzed. NHANES included participants from a nationally representative sample of non-institutionalized residents of the United States. The survey was conducted by the National Center for Health Statistics (NCHS) and included laboratory and interview information.
Samples were weighted to be representative of the US population so population estimates could be made. The NHANES sampling weights account for
Results
Table I shows the characteristics of the unweighted study population of 1837 persons representing a weighted population of 31,285,208 adolescents between 12 and 19 years of age. The average age was 15.4 years, which was similar across all BMI categories. Overweight and risk for overweight adolescents reported less physical activity than normal weight adolescents. Overall, the majority of normal-weight adolescents were classified as being of moderate fitness on the CV fitness test. More than
Discussion
Adolescents with BMI percentile of 75 to 84.9, which represents approximately 1.2 million US adolescents, have high HOMA-IR levels. Although several previous studies have identified an increase in insulin resistance in the overweight and risk for overweight adolescent populations,9, 13, 14 this is the first study to show high HOMA-IR levels in the BMI percentile of 75 to 84.9, a group considered to be “normal” weight.
Adolescents with insulin resistance tend to have higher total cholesterol with
References (26)
- et al.
Prevalence of Overweight and Obesity in the United States, 1999-2004
JAMA
(2006) Extent of overweight among US children and adolescents from 1971 to 2000
Int J Obes
(2004)- et al.
Prevalence of overweight and obesity among us children, adolescents, and adults, 1999-2002
JAMA
(2004) - et al.
2000 CDC Growth Charts for the United States: methods and development
Vital & Health Statistics - Series 11: Data from the National Health Survey
(2002) - et al.
Pediatric obesity and insulin resistance: chronic disease risk and implications for treatment and prevention beyond body weight modification
Annu Rev Nutr
(2005) - et al.
Insulin resistance as a predictor of age-related diseases
J Clin Endocrinol Metab
(2001) Presence of diabetes risk factors in a large U.S. eighth-grade cohort
Diabetes Care
(2006)Prevalence of diabetes and impaired fasting glucose levels among US adolescents
Arch Pediatr Adolesc Med
(2006)- et al.
Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000
J Pediatr
(2005) - National Center for Health Statistics. NHANES Cardiovascular Fitness Procedure Manual. Available at:...
Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistant among obese children and adolescents
Pediatrics
Are ethnic differences in insulin sensitivity explained by variation in carbohydrate intake?
Diabetologia
Prevalence and trends of a metabolic syndrome phenotype among US adolescents, 1999-2000
Diabetes Care
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2009, Metabolism: Clinical and ExperimentalCitation Excerpt :Our study has the following limitations. First, participants were not a random selection of the United States, as in the National Health and Nutrition Examination Survey [29], but came from a biracial schoolgirl population and from a health maintenance organization program. Thus, the data, although suggestive, need to be confirmed and cannot be extrapolated to all adolescent girls.