Clinical Practice Guidelines
Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine

https://doi.org/10.1016/j.joim.2018.05.002Get rights and content
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Abstract

Traditional Chinese medicine (TCM) is an important part of the treatment of primary liver cancer (PLC) in China; however, the current instructions for the integrative use of traditional Chinese and Western medicine for PLC are mostly based on expert opinion. There is no evidence-based guideline for clinical practice in this field. Therefore, the Shanghai Association of Chinese Integrative Medicine has established a multidisciplinary working group to develop this guideline, which focuses on the most important questions about the use of TCM during PLC treatment. This guideline was developed following the methodological process recommended by the World Health Organization Handbook for Guideline Development. Two rounds of questionnaire survey were performed to identify clinical questions; published evidence was searched; the Grading of Recommendations Assessment, Development and Evaluation approach was used to evaluate the body of evidence; and recommendations were formulated by combining the quality of evidence, patient preferences and values, and other risk factors. The guideline was written based on the Reporting Items for Practice Guidelines in Healthcare tool. This guideline contains 10 recommendations related to 8 questions, including recommendations for early treatment by TCM after surgery, TCM combined with transcatheter arterial chemoembolization for advanced PLC, TCM drugs for external use, and acupuncture and moxibustion therapy.

Keywords

Primary liver cancer
Clinical practice guidelines
Traditional Chinese medicine
Integrative medicine

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Members of the Chinese Integrative Therapy of Primary Liver Cancer Working Group: The list of the Chinese Integrative Therapy of Primary Liver Cancer Working Group members, sorted by the initials of their family names, is shown below: Xin-yu Bi, Department of Liver Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China; Min-shan Chen, Department of Liver Surgery, Cancer Center of Sun Yat-sen University, Guangzhou 510060, China; Yao-long Chen, Chinese GRADE Center/Evidence-based Medicine Center, Lanzhou University, Lanzhou 730000, China; Zhe Chen, Department of Chinese Medical Oncology, Changhai Hospital, Shanghi 200433, China; Jia Fan, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Li Feng, Department of Traditional Chinese Medicine, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China; Xue-wu Huang, Department of Oncology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Bai Li, Department of Rehabilitative Medicine, Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China; Ge Li, Department of Oncology, Dalian Hospital of Traditional Chinese Medicine, Dalian 116013, China; Le-qun Li, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China; Nan Li, Department of Liver Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai 200433, China; Qi Li, Department of Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Hong-sheng Lin, Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Li-zhu Lin, Department of Oncology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Chang-quan Ling, Department of Integrative Oncology, Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China; Hui Liu, Department of Liver Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai 200433, China; Zhi-qiang Meng, Department of Integrative Traditional Chinese and Western Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Shu-kui Qin, Cancer Center of Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing 210002, China; Min-jie Shang, Department of Liver Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China; Feng Shen, Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China; Jue Sun, Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China; Peng Wang, Department of Integrative Traditional Chinese and Western Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Xi Wang, Department of Oncology, The 117th Hospital of PLA, Hangzhou 310013, China; Zhong-qi Wang, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Qing Wu, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Ling Xu, Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Zhen-ye Xu, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Yun-ke Yang, Department of Traditional Chinese Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Dong-feng Yin, Department of Traditional Chinese Medicine, First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032, China; Xiao-qiang Yue, Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, Shanghai 200003, China; Pu-hua Zeng, Department of Oncology, Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha 410006, China; Xiao-feng Zhai, Department of Integrative Oncology, Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China; Zhi-wei Zhang, Department of Liver Surgery, Tongji Hospital, Tongji Medical College, Huangzhong University of Science & Technology, Wuhan 430030, China; Jun Zhou, Department of Oncology, Eastern Hospital, Tongji University, Shanghai 200120, China; Qing-hui Zhou, Department of of Acupuncture-Moxibustion and Tuina, Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China; Wei-ping Zhou, Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China.