Review ArticleRegulated Cell Death in Pulpitis
Section snippets
Classification of RCD
The NCCD has released 5 guidelines and recommendations dealing with the classification of cell death, which has been recently updated based on morphologic appearance, biochemical features, and functional criteria3. We focused on 4 types of RCD having been identified in pulpitis (ie, apoptosis, pyroptosis, NETosis, and nemesis) and their communication controlling the shift in cell death pathways. Table 1 summarizes 4 RCD modalities and their inhibitors based on NCCD guidelines and recent
Intercommunication between Apoptosis, Pyroptosis, and NETosis
As we learn more about the roles of RCD in pulpitis, it is noteworthy that different RCD signaling pathways are interconnected and even inconvertible. As such, the cross talk of RCD could also be critical for cell fate determination and the extent of pulp inflammation. In the following text, we discuss major nodes between apoptosis, pyroptosis, and NETosis.
Conclusion
Even though great advances have been made in the field of RCD in recent decades, the current knowledge on RCD in pulpitis remains limited. Until recently, researchers have identified apoptosis9, pyroptosis10, and NETosis11 in pulpitis. However, most of the current literature on RCD in pulp inflammation focuses on 1 RCD modality, and it is difficult to identify which types of RCD play the prominent role in the early or late stages of pulpitis, respectively. It is conceivable that the switch
Acknowledgments
Minchun Huang and Chaoning Zhan contributed equally to this study.
Supported by the National Natural Science Foundation of China (grant nos. 81500870 and 81971902) and the Natural Science Foundation of Guangdong Province (grant no. 2016A030313590).
The authors deny any conflicts of interest related to thist study.
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