Cortical event-related potentials in Alzheimer's disease and frontotemporal lobar degeneration
Section snippets
1.Introduction
The clinical differentiation between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FLTD)-type senile dementias is difficult to obtain, although the neuropathological changes in AD are distinct from those in FLTD. AD is characterized by cognitive deficits and behavioral and personality changes, with obvious memory impairment [1]. FLTD is a clinically and pathologically heterogeneous syndrome [2], [3], [4], with some variants having considerable symptomatic overlap with AD [5],
2.1. Subjects
We recruited study subjects from patients treated at the cognitive impairment clinic of Tianjin Huan Hu Hospital (Tianjin, China) between November 2009 and February 2011. Thirty five healthy subjects (mean age 68.03 ± 10.793 years, range 35–88 years) were recruited from the hospital medical examination center. Forty two patients with AD (mean age 69.79 ± 9.201 years, range 48–85 years) met the common criteria of the NINCDS-ADRDA [24] and DSM-IV (1994). Twenty nine patients with bvFTD (mean age 71.55 ±
3. Results
The results of demographic and clinical analyses in the three groups are shown in Table 1. The total MMSE mean score of AD patients was 20.21 ± 5.340 ranging from 9 to 29. The total MMSE mean score of bvFTD patients was 19.28 ± 4.590 ranging from 8 to 26. The mean MMSE of healthy controls was 25.77 ± 2.276 ranging from 22 to 29. No significant differences in sex, age, handedness, and education level were observed among the groups. The subjects in the AD and bvFTD groups had lower MMSE scores than
4. Discussion
The aim of the present study was to investigate the diagnostic potential of ERP subcomponents in AD and bvFTD. There was no significant correlation between the severity of AD and bvFTD assessed by the MMSE scores and P300 amplitude or latency, while a negative correlation was observed between MMSE scores and P300 latencies at the Pz regions in the control group. In previous studies, correlations between P300 latency and normal aging or cognitive assessment scores have been observed in healthy
Disclosure statement
The authors have no conflicts of interest to disclose.
Acknowledgments
The authors thank Prof. Zhuang Cui (Tianjin Medical University) for the statistic work on our study.
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2022, International Journal of PsychophysiologyCitation Excerpt :Moreover, N400 and P600 repetition effects showed a prediction accuracy of 82.0 % and 91.0 % in the progression from MCI to AD, respectively (Olichney et al., 2008). Even though a great number of studies did not detect ERP differences of latency or amplitude among AD, MCI and normal aged people in components concerning early sensory processing (references as forementioned), MMN (Brønnick et al., 2010; Tales and Butler, 2006), N200 (Chen et al., 2015; Gungor et al., 2005; Kurita et al., 2010), P300 (Cespón et al., 2015; Stothart et al., 2015), N400 (Saavedra et al., 2012), and so on, the major alternations of ERP component were usually prolonged latency and reduced amplitude in AD and MCI (except for P50). However, we also mentioned several controversial findings, for example the results of P100 amplitude in AD (Cheng and Pai, 2010; Fide et al., 2019).
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