Journal of Molecular Biology
Volume 426, Issue 22, 11 November 2014, Pages 3729-3743
Restricted Diversity of Antigen Binding Residues of Antibodies Revealed by Computational Alanine Scanning of 227 Antibody–Antigen Complexes
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open access
Graphical abstract
Abbreviations
scFv
single chain Fv
FR
framework region
CDR
complementarity-determining region
PDB
Protein Data Bank
GkF5
Gankyrin–scFv F5
Keywords
protein–protein interaction
X-ray crystal structure analysis
binding free energy
antibody library
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Copyright © 2014 The Authors. Published by Elsevier Ltd.