Elsevier

Journal of Infection

Volume 76, Issue 3, March 2018, Pages 307-310
Journal of Infection

Letters to the Editor
Dynamic and direct pathogen load surveillance to monitor disease progression and therapeutic efficacy in central nervous system infection using a novel semi-quantitive sequencing platform

https://doi.org/10.1016/j.jinf.2017.11.002Get rights and content

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Declaration

We confirm that each individual named as an author meets the journal's criteria for authorship and neither the entire paper nor any part of its content has been published or accepted elsewhere. It is not being submitted to any other journal.

Funding

This work was supported by no foundation.

A conflict of interest

All authors: No potential conflicts of interest.

Acknowledgements

Written consent for publication was obtained from the patient's family, with thanks to the Huashan Hospital of Fudan University.

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    As our samples were limited, further clinical studies on large samples were needed to verify our results. A study by Wang, S, et al. [47] found that the specificity of NGS for diagnosis of TBM reached 100%, which provided a new alternative diagnostic method for TBM and recommended NGS as a first-line detection method for TBM.The results from this study were comparable to our investigation but lacked the use of an Xpert MTB/RIF assay. Our study also found that the high specificity of NGS could be combined with traditional detection methods to achieve higher diagnostic rates, which was not found in the above study.

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Jing-Wen Ai, Hao-Cheng Zhang contributed equally to this manuscript.

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