The role of CD8+ T-cell responses in the pathogenesis of HIV-2, a naturally contained human retroviral infection

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Abstract

Background: While a significant proportion of HIV-2-infected individuals are asymptomatic and maintain undetectable viral loads (controllers), 15-20% progress to AIDS and are predicted by detectable viraemia. Identifying immune correlates that distinguish these two groups should provide insights into how a potentially pathogenic retrovirus can be naturally controlled.

Methods: We performed a detailed study of HIV-2-specific cellular responses in a unique community cohort in Guinea-Bissau

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