Oligoadenylate synthetase 3 S381R gene polymorphism is associated with severity of EV71 infection in Chinese children
Section snippets
Background
Enterovirus 71 (EV71) is a positive-sense RNA virus belonging to species Enterovirus A, and is a member of family Picornaviridae. Since it was first isolated from stool specimen in a child with central nervous system in 1969, a large outbreak of EV71 infections have occurred across the Asia-Pacific region, causing great economic and social burden [[1], [2], [3], [4]]. Compared with other enteroviruses, EV71 can cause fatal neurological complications because of its neurotropism [5]. There is a
Objectives
In the present study, the purpose was (1) to investigate whether the OAS3 S381R gene polymorphism is associated with the susceptibility and severity of EV71 infection in Chinese children. (2) to evaluate whether the IFN-γ levels are correlated with OAS3 S381R gene polymorphism in patients with the severity of EV71 infection.
Subjects
We investigated 260 Chinese Han children with EV71 infection (137 males and 123 females) at the Pediatric Department of the Affiliated Hospital of Qingdao University and Qingdao Women & Children Hospital, China, between May 2013 and August 2015. A total of 243 children (128 males and 115 females) undergoing a health check-up in hospital were recruited as the control population during the same period. Of the EV71-infected patients, 11 children were excluded because of underlying diseases:
Baseline demographics and characteristics
In this study, we investigated a group of 249 EV71-infected patients (134 males and 115 females) aged from 0.5 to 13.8 years. There were 151 mild cases (80 males and 71 females, aged 4.85-5.83 years) and 98 severe cases (54 males and 44 females, aged 4.67–6.13 years). As shown in Table 1, no significant difference was observed in gender (P = .743) and age (P = .883) between mild and severe cases. However, compared to mild cases, severe cases had longer duration of fever days (P < .01), more
Discussion
EV71 infection can affect multiple tissues and organs, causing severe neurological complications. Severe cases caused by EV71 have higher morbidity and mortality, emerged as a serious global public health problem. Various factors can influence the different physical responses to the same infectious agent, including the virulence of the pathogen and the ability on the part of the host to resist infection. Host genetic factors are thought to influence the susceptibility to infection as well as
Funding
This work was financially supported by the National Natural Science Foundation of China (grant number 31640047), and technically helped by Genesky Biotechnologies Inc., Shanghai, China. The authors thank their patients for blood donation and agreement to participate in this study.
Ethics approval
All steps included in the study involving human participants obeyed the ethical standards of Ethics Review Committee of the Medical College of Qingdao University.
Competing interest
None to disclose.
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Association of CD14 rs2569190 G/A genetic polymorphism with the severity of enterovirus 71 infection in Chinese children
2020, VirologyCitation Excerpt :Although we collected patients infected with EV71 from 2012 to 2014, we still need to test the subtype of EV71 to ensure that all EV71-infected cases belong to the same subtype and exclude the effect caused by the variants of EV71 virus itself. In addition to this, the polymorphisms of HLA-A33, OAS3 and some cytokines have been shown to be associated with EV71 infection (Chang et al., 2016; Liu et al., 2018; Lv et al., 2013; Zhao et al., 2017). In a word, an increasing number of studies indicated that the polymorphisms of EV71 and host genes and the subgenotypes of EV71 were related to EV71 susceptibility and the severity of EV71 infection.
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