Myxoid Liposarcoma in a Cat

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Introduction

Liposarcoma is a rare tumour of domestic animals that is most frequently described in dogs. We describe the first case of myxoid liposarcoma in the proximal humerus of a cat.

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Materials and Methods

A 15-year-old male cat presented with a gradually expanding swelling in the proximal region of the left humerus. The left forelimb, including the humerus and scapula, was amputated. Tumour samples were processed routinely and stained with haematoxylin and eosin, oil red O, alcian blue (pH 2.5) and Masson's trichrome. Immunochemistry was used to assess expression of vimentin, pancytokeratin and S-100.

Results

Grossly, the tumour was tan to white, soft and multilobulated. Areas of haemorrhage and necrosis were prominent. Microscopically, round to polygonal cells, arranged in sheets, contained numerous clear, round, variably sized and well-defined intracytoplasmic vacuoles. Nuclear atypia and frequent mitosis were present. Oil red O verified the presence of fat in the cytoplasmic vacuoles. Alcian blue showed a prominent background of myxoid extracellular substance. Additionally, tumour cells were

Conclusions

The gross, microscopical, histochemical and immunohistochemical findings were consistent with a diagnosis of myxoid liposarcoma.

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