Original ResearchThe Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice
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Keywords
CCl4
Systems Genetics
Liver Toxicity and Injury
Genome-Wide Association Study
Abbreviations used in this paper
bp
base pair
CCl4
carbon tetrachloride
CPA%
collagen proportionate area
ECM
extracellular matrix
eQTL
expression quantitative trait locus
GWAS
genome-wide association study
HCV
hepatitis C virus
HMDP
Hybrid Mouse Diversity Panel
HSC
hepatic stellate cell
MUP
mouse urinary protein
NAFLD
nonalcoholic fatty liver disease
NASH
nonalcoholic steatohepatitis
SD
standard deviation
SNP
single nucleotide polymorphism
TPM
transcripts per million
WGCNA
weighted gene coexpression network analysis
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Conflicts of interest The authors disclose no conflicts.
Funding Supported by Sigrid Juselius Foundation (IT), Orion-Farmos Research Foundation (IT), K99 HL121172 (MC), HL28481, HL144651 and DK117850 (AJL), K08DK088998 (SWB), Ruth L. Kirschstein National Research Service Award T32HL069766 (BKF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Authors share co-first authorship.
© 2021 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.