Journal of Biological Chemistry
Research ArticleEditors' PickDesigner proteins that competitively inhibit Gαq by targeting its effector site
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Mahmud Hussain is a senior-level scientist and a team leader at Precision BioSciences Inc, USA. His current research involves engineering antibodies aimed at developing chimeric antigen receptor T (CAR-T) cell therapy to treat several forms of cancer. As highlighted in his recent JBC article, Mahmud utilizes nature-inspired and structure-guided combinatorial biology tools to discover novel solutions in protein–protein interaction for developing CAR-T cell therapy.
Matthew C. Cummins is a graduate student in the Department of Pharmacology at the University of North Carolina at Chapel Hill. He studies protein engineering methods and G proteins. Unfortunately, few inhibitors against G proteins exist, and those that do have limitations. Matt is using computational protein design to engineer de novo proteins that are tailored to inhibit G proteins.
Present addresses for Mahmud Hussain: Precision Biosciences, Durham, North Carolina, USA.
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These authors contributed equally to this work.