Original ArticleAssociations among smoking status, lifestyle and lipoprotein subclasses
Section snippets
Study sample
The prospective Melbourne Collaborative Cohort Study recruited 41,514 subjects ages 27 to 80 years in 1990 to 1994. Twenty-four percent were southern European migrants, deliberately oversampled to extend the range of lifestyle factors and genetic variation. Study details have been published elsewhere.12 Approval from The Cancer Council Victoria’s Human Research Ethics Committee and written informed consent from participants were obtained. Baseline examination included face-to-face interviews
Subjects
Baseline characteristics in Table 1 show differences between males and females subjects in the comparability of smokers and former smokers with nonsmokers. For women, current smokers had a lower mean body mass index than nonsmokers and were more likely to be within normal weight limits. Compared with female nonsmokers, former smokers were less likely to have been born in a Mediterranean country, to have primary education only, and to be obese. Additionally, female former smokers were more
Discussion
In this work we demonstrate that female smokers have a more atherogenic lipoprotein profile than nonsmokers, although this profile is less adverse in ex-smokers. Differences are seen in both conventional lipid concentrations and in NMR-determined lipoprotein profiles and are independent of lifestyle-related factors. There were few smoking-related changes in lipoproteins for males.
Acknowledgments
The authors acknowledge the MCCS investigators and participants.
References (30)
- et al.
Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy
Clin Lab Med
(2006) - et al.
LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)
Atherosclerosis
(2007) - et al.
Smoking intensity and lipoprotein abnormalities in active smokers
J Clin Lipidol
(2009) - et al.
NMR-determined lipoprotein subclass profile predicts type 2 diabetes
Diabetes Res Clin Pract
(2009) - et al.
Smoking and smoking cessation-the relationship between cardiovascular disease and lipoprotein metabolism: A review
Atherosclerosis
(2008) - et al.
Effects of cigarette smoking on fasting triglyceride, total cholesterol, and HDL-cholesterol in women
Am Heart J
(1983) Diet, lipids and coronary heart disease
Endocrinol Metab Clin North Am
(1990)- et al.
Triglycerides and small dense LDL: the twin Achilles heels of the Friedewald formula
Clin Biochem
(2003) - et al.
Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data
Br Med J
(1989) - et al.
Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution
Eur J Clin Invest
(1993)
Tobacco smoking, estrogen receptor {alpha} gene variation and small low density lipoprotein level
Hum Mol Genet
Smoking, lipoproteins and coronary heart disease risk: Data from the Munster Heart Study (PROCAM)
Eur Heart J
Cigarette smoking and blood lipids and lipoproteins
Curr Topics Pharmacol
Quantification of lipoprotein subclasses by proton nuclear magnetic resonance-based partial least-squares regression models
Clin Chem
Atherogenic lipoprotein particles in atherosclerosis
Circulation
Cited by (9)
Healthy lifestyle, plasma metabolites, and risk of cardiovascular disease among individuals with diabetes
2023, AtherosclerosisCitation Excerpt :For instances, Mendelian randomization study indicated causal effects of increased body mass index or waist-hip ratio on multiple metabolic biomarkers including unfavorable lipoprotein subclass profile, increased concentration of branched-chain amino acids and inflammation markers [9,22]. For cigarette smoking, studies observed higher medium and small LDL and lower large HDL particle concentrations for female smokers than nonsmokers [23,24]. For alcohol intake, despite its effect on health is controversial, it has long been observed that moderate alcohol intake was associated with lower risk of coronary heart disease [25].
Protective lifestyle behaviours and lipoprotein particle subclass profiles in a middle-to older-aged population
2020, AtherosclerosisCitation Excerpt :In our study, smoking status was independently associated with total TRL, medium VLDL and small VLDL. Using a sample of 612 subjects, Beauchamp et al. [42] found female smokers to have a more atherogenic lipoprotein profile than non-smokers; these results were consistent for both conventional lipid concentrations and NMR-determined lipoprotein profiles. However, some sex-specific smoking-related changes were observed among males.
Impact of Smoking Status on Lipoprotein Subfractions: Data from an Untreated Chinese Cohort
2017, Biomedical and Environmental SciencesMetabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility
2024, European Journal of EpidemiologyAssociations between obesity, adverse behavioral patterns and cardiovascular risk factors among adolescent inhabitants of a Greek island
2017, Journal of Pediatric Endocrinology and MetabolismDysfunctional HDL and atherosclerotic cardiovascular disease
2016, Nature Reviews Cardiology