Biologics and immunotherapyRole of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy
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Key words
Allergy
IgE
antibodies
variable heavy chain families
allostery
Fc receptor binding
superantigen binding
Abbreviations used
CDR
Complementarity-determining region
C-region
Constant region
FWR
Framework
ka
Association rate constant
KD
Equilibrium dissociation constant
kd
Dissociation rate constant
PDB
Protein Data Bank
spA
Protein A
VH
Variable heavy chain
V-region
Variable region
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Supported by A*STAR Industry Alignment Fund (IAF) grant IAF111149 and institute core funds.
Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.
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These authors contributed equally to this work.
© 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.