Original Investigation
Editorial Comment
The Core Value of Cost-Effectiveness Analyses

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Key Words

aortic stenosis
appropriate use
cost-benefit analysis
heart valve prosthesis
quality-adjusted life-years
transcatheter valve therapy

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Dr. Krumholz is supported by grant U01 HL105270-05 (Center for Cardiovascular Outcomes Research at Yale University) from the National Heart, Lung, and Blood Institute; is the recipient of research agreements from Medtronic and Johnson & Johnson (Janssen), through Yale University, to develop methods of clinical trial data sharing; is the recipient of a grant from Medtronic in collaboration with the Food and Drug Administration, through Yale University, to develop methods and facilitate best practices for medical device surveillance; and chairs a cardiac scientific advisory board for United Healthcare. Dr. Dhruva has reported that he has no relationships relevant to the contents of this paper to disclose. Neil Moat, MBBS, served as Guest Editor for this paper.

Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.