State-of-the-Art Paper
Potential Role of the Ubiquitin-Proteasome System in Atherosclerosis: Aspects of a Protein Quality Disease

https://doi.org/10.1016/j.jacc.2008.02.047Get rights and content
Under an Elsevier user license
open archive

Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.

Abbreviations and Acronyms

Abeta
amyloid beta protein
APP
amyloid precursor protein
ER
endoplasmic reticulum
ERAD
endoplasmic reticulum-associated protein degradation
HSP
heat shock protein
LDL
low-density lipoprotein
ROS
reactive oxygen species
TIA
transient ischemic attack
UPS
ubiquitin-proteasome system

Cited by (0)

Supported by the National Institutes of Health (R01 HL63911-04, K24 HL69840-01), the Mayo Stiftung, and the Mayo Foundation.