State-of-the-Art ReviewThe Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications
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Graphical abstract
Key Words
cardiac regeneration
disease modeling
drug discovery
induced pluripotent stem cells
Abbreviations and Acronyms
ESC
embryonic stem cell(s)
iCM
induced pluripotent stem cell–derived cardiomyocyte(s)
iEC
induced pluripotent stem cell–derived endothelial cell(s)
iPSC
induced pluripotent stem cell(s)
MI
myocardial infarction
SCID
severe combined immunodeficient
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Supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute Cardiovascular Cell Therapy Research Network (5UM1 HL113456-02, UM1-HL113530, 5UM1-HL087366-07), National Institute of Health HL-78825, National Heart, Lung, and Blood Institute Training Program in Mechanisms and Innovation in Vascular Disease (1T32HL098049-01A1), and National Institutes of Health/National Center for Advancing Translational Sciences (UL1-TR001427 and 1R01 HL125224). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
© 2016 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.