Journal of American Association for Pediatric Ophthalmology and Strabismus
Major ArticleQuantity and duration of exposure to general anesthesia for pediatric patients with retinoblastoma
Section snippets
Subjects and Methods
This study was approved by the Phoenix Children Hospital Institutional Review Board. The medical records of pediatric patients undergoing treatment of Rb from January 2011 to February 2022 at Phoenix Children’s Hospital were retrospectively reviewed. Patients who received a portion of their oncologic or ophthalmologic care outside of our institution and patients lost to follow-up were excluded. The following data were extracted from record: patient demographics, family history of Rb, presenting
Results
A total of 43 patients were included; demographics and clinical characteristics are summarized in eSupplement 1 (available at jaapos.org). Almost all patients in the study (95%) were diagnosed with retinoblastoma at <4 years of age, at a median age of 20 months (range, 1-134 months) in children with unilateral disease, and a median of 6 months (range, 0-11 months) in children with bilateral disease.
Total general anesthesia time was 48,991 minutes (816.5 hours) for 610 procedures in the 43
Discussion
During neuronal development and synaptogenesis, N-methyl-D-aspartate (NMDA) glutamate blockade or γ-aminobutyric acidA (GABAA) activation via anesthetic agents can interfere with dendritic development and promote apoptotic degeneration of immature neurons.19 Other possible causes for the purported effects of lengthy anesthesia include impaired growth factor signaling, neuroinflammation, oxidative stress, and epigenetic modification.20 Although studies analyzing the neurodevelopmental
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Cited by (1)
Presented as a poster at the 47th Annual Meeting of the American Association for Pediatric Ophthalmology and Strabismus, Scottsdale, Arizona, March 23-27, 2022.