Dermatology grand rounds at the NIHRecurrent scarring papulovesicular lesions on sun-exposed skin in a 22-year-old man
Section snippets
History
A 22-year-old white man has been followed in the Clinical Center at the National Institutes of Health (NIH) for recurrent outbreaks of scarring herpetiform lesions on sun-exposed areas. The patient and/or parents signed consent forms and were followed under NIH protocols that were approved by the institutional review boards of the National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute.
He reported itching and burning within
Discussion
HV is a rare childhood photodermatosis associated with latent EBV infection.1 Typical HV has outbreaks that begin during childhood or early adolescence without systemic involvement and usually resolve by young adulthood.2, 3 Some cases persist into adulthood with elevated levels of EBV in the blood.4, 5 Most cases of typical HV have been diagnosed in the United States, Europe, Australia, South Africa, and Asia.5, 6, 7, 8 In contrast, patients with severe HV-like eruptions are often from Asia9,
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Cited by (4)
Hydroa vacciniforme-like lymphoproliferative disorder: An EBV disease with a low risk of systemic illness in whites
2019, BloodCitation Excerpt :Patients with HVLPD were defined as having papulovesicular skin lesions in sun-exposed areas that healed with scarring and markedly elevated levels of EBV DNA (>10 000 copies/mL) in the blood with high levels of EBV DNA in T or NK cells. Patients 1,10 11,11 and 1312 were reported previously. Patients with classic HVLPD had no persistent systemic symptoms, lymphadenopathy, hepatosplenomegaly, hepatitis, hemophagocytic syndrome, or NK-cell lymphocytosis, while those with systemic HVLPD had ≥1 of these persistent symptoms or signs of extracutaneous disease (based on prior criteria6).
Actinic Prurigo and Hydroa Vacciniforme
2019, Current Dermatology ReportsLongitudinal Observation of Pediatric Dermatology Patients
2019, Longitudinal Observation of Pediatric Dermatology Patients
Supported by the Intramural Research Programs of the Center for Cancer Research, National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Human Genome Research Institute, National Institutes of Health (NIH). Support for Ms. Levoska was made possible through the NIH Medical Research Scholars Program, a public-private partnership supported jointly by the NIH and generous contributions to the Foundation for the NIH from the Doris Duke Charitable Foundation, the American Association for Dental Research, the Colgate-Palmolive Company, Genentech, and other private donors. For a complete list, visit the foundation website at http://www.fnih.org.
Conflicts of interest: None disclosed.
Reprints are not available from the authors.