Journal of the American Academy of Child & Adolescent Psychiatry
New researchIdentifying Adolescents at Risk for Depression: A Prediction Score Performance in Cohorts Based in 3 Different Continents
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This work is supported by research grants from Brazilian public funding agencies to Drs. Kieling and Rohde: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS). This article is based on data from the study “Pelotas Birth Cohort, 1993” conducted by Postgraduate Program in Epidemiology at Universidade Federal de Pelotas, currently supported by the Wellcome Trust through the program entitled Major Awards for Latin America on Health Consequences of Population Change. The E-Risk Study is funded by the UK Medical Research Council (G1002190). Additional support was provided by the National Institute of Child Health and Human Development (HD077482) and by the Jacobs Foundation. Dr. Arseneault is the Mental Health Leadership Fellow for the UK Economic and Social Research Council. The Dunedin Study is supported by the New Zealand Health Research Council, New Zealand Ministry of Business, Innovation, and Employment, National Institute on Aging Grant R01AG032282 and UK Medical Research Council Grant MR/P005918/1. The Identifying Depression Early in Adolescence (IDEA) project is funded by an MQ Brighter Futures grant (MQBF/1 IDEA). Additional support was provided by the UK Medical Research Council (MC_PC_MR/R019460/1) and the Academy of Medical Sciences (GCRFNG/100281) under the Global Challenges Research Fund. The views expressed are those of the authors. None of the funders played any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; and decision to submit the manuscript for publication.
Author Contributions
Conceptualization: Rohde, Kieling
Data curation: Rocha, Anselmi, Arseneault, Barros, Caspi, Danese, Gonçalves, Harrington, Menezes, Moffitt, Poulton, Wehrmeister, Kieling
Formal analysis: Rocha, Fisher, Caye, Harrington, Houts, Menezes, Moffitt, Mondelli, Rohde, Wehrmeister, Kieling
Funding acquisition: Fisher, Arseneault, Barros, Caspi, Mondelli, Kieling
Investigation: Fisher, Caye, Anselmi, Arseneault, Barros, Caspi, Danese, Gonçalves, Menezes, Moffitt, Poulton, Rohde, Kieling
Methodology: Rocha, Fisher, Caye, Arseneault, Barros, Caspi, Danese, Gonçalves, Harrington, Houts, Menezes, Moffitt, Mondelli, Poulton, Rohde, Wehrmeister, Kieling
Project administration: Arseneault, Mondelli, Kieling
Resources: Kieling
Supervision: Fisher, Kieling
Validation: Caye
Writing – original draft: Rocha, Kieling
Writing – review and editing: Rocha, Fisher, Caye, Anselmi, Arseneault, Barros, Caspi, Danese, Gonçalves, Harrington, Houts, Menezes, Moffitt, Mondelli, Poulton, Rohde, Wehrmeister, Kieling
ORCID
Thiago Botter-Maio Rocha, MD, PhD: https://orcid.org/0000-0002-3080-6078
Helen L. Fisher, PhD: https://orcid.org/0000-0003-4174-2126
Louise Arseneault, PhD: https://orcid.org/0000-0002-2938-2191
Fernando C. Barros, MD, PhD: https://orcid.org/0000-0001-5973-1746
Andrea Danese, MD, PhD: https://orcid.org/0000-0001-8718-5412
Helen Gonçalves, PhD: https://orcid.org/0000-0001-6470-3352
Hona Lee Harrington, BA: https://orcid.org/0000-0002-0225-0607
Valeria Mondelli, MD, PhD: https://orcid.org/0000-0001-8690-6839
Richie Poulton, PhD: https://orcid.org/0000-0002-1052-4583
Fernando Wehrmeister, PhD: https://orcid.org/0000-0001-7137-1747
Christian Kieling, MD, PhD: https://orcid.org/0000-0001-7691-4149
The authors are extremely grateful to the individuals who participated in the studies at each of the sites and to all members of the IDEA consortium and the study teams for their dedication, hard work, and insights. The authors thank all members of the ProDIA group for their assistance in the development of this work. The authors would like to especially thank João Ricardo Sato, PhD, of the Universidade Federal do ABC for his thoughtful insights into the initial version of this study and Rachel Latham, PhD, of King’s College London for assistance with checking the statistical analysis for the E-Risk study.
Disclosure: Dr. Mondelli has received research funding from Johnson and Johnson, a pharmaceutical company interested in the development of anti-inflammatory strategies for depression, but the research described in this article is unrelated to this funding. Dr. Rohde has been on the speakers’ bureau/advisory board and/or has acted as a consultant for Eli Lilly and Company, Janssen-Cilag, Novartis, and Shire (a Takeda company) in the last 3 years. He has received authorship royalties from Oxford University Press and ArtMed. He has received travel awards from Shire for taking part in the 2014 American Psychiatric Association 2014 Annual Meeting. The ADHD and Juvenile Bipolar Disorder Outpatient Programs chaired by him have received unrestricted educational and research support from the following pharmaceutical companies in the last 3 years: Eli Lilly and Company, Janssen-Cilag, Novartis, and Shire. Dr. Kieling is an Academy of Medical Sciences Newton Advanced Fellow and has received grant or research support from Brazilian governmental research funding agencies (Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq], Coordenação de Aperfeiçoamento de Pessoal de Nível Superior [CAPES], and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul [Fapergs]) and United Kingdom funding agencies (MQ, Medical Research Council, and Academy of Medical Sciences). He has served on the editorial boards of Archives of Clinical Psychiatry, Global Mental Health, and Jornal Brasileiro de Psiquiatria. He has received authorship royalties from Brazilian publishers ArtMed and Editora Manole. Drs. Rocha, Fisher, Caye, Anselmi, Arseneault, Barros, Caspi, Danese, Gonçalves, Houts, Menezes, Moffitt, Poulton, and Wehrmeister and Ms. Harrington have reported no biomedical financial interests or potential conflicts of interest.