Fulminant myocarditis may occur following SARS-CoV2 mRNA vaccination requiring mechanical cardiac support.
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It is important to recognize features of systemic hyperinflammatory syndrome following SARS-CoV2 mRNA vaccination.
Abstract
Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous recovery. We herein report two cases of fulminant myocarditis following BNT162b2 mRNA Covid-19 vaccination associated with systemic hyperinflammatory syndrome and refractory shock requiring support with veno-arterial extracorporeal membrane oxygenation.