Weissella paramesenteroides WpK4 plays an immunobiotic role in gut-brain axis, reducing gut permeability, anxiety-like and depressive-like behaviors in murine models of colitis and chronic stress
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Graphical abstract
Mood disorders could worsen the course of inflammatory bowel disease. In this study, we evaluated the role of a probiotic bacteria in the contexts of colitis and stress, separately. W. paramesenteroides WpK4 acted as an immunobiotic, reducing inflammation at local and systemic level, promoting gut barrier and reducing anxiety-like and depressive-like behaviors in mice.
Keywords
Colitis
Comorbidity
Mood disorder
Probiotics
Psychobiotics
Abbreviations
CEUA
Institutional Ethics Committee on Animal Use (Comissão de Ética no Uso de Animais)
Cpm
represents the counts of radioactivity per minute
Ct
Control group, without challenge and treatment
DAI
disease activity index
DSS
Dextran sulfate sodium or mice challenged with DSS
IDO1
Indoleamine 2,3-dioxygenase 1
IBD
Inflammatory bowel disease
IRF
Interferon-regulatory factor
MyD88
Myeloid differentiation primary response 88
NLRP3
NLR family, pyrin domain containing 3
TLR
toll-like receptors
TRIF
TIR-domain-containing adapter-inducing interferon-β
WpK4
Weissella paramesenteroides WpK4 or mice treated with WpK4
WpK4Dss
Colitis mice treated with WpK4
WpK4Stress
Stressed mice treated with WpK4
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