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Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder

Published online by Cambridge University Press:  16 April 2020

E. Perrier ,
F. Pompei ,
G. Ruberto ,
E. Vassos ,
D. Collier  and
S. Frangou
E. Perrier
Affiliation:
Medizinische Fakultät, Universität zu Köln, Germany Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
F. Pompei
Affiliation:
Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
G. Ruberto
Affiliation:
Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
E. Vassos
Affiliation:
Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK
D. Collier
Affiliation:
Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK
S. Frangou*
Affiliation:
Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
*
*Corresponding author. Tel.: +44 207 8480425. E-mail address: sophia.frangou@kcl.ac.uk (S. Frangou).
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Abstract

Background

The polymorphism rs1006737 within the CACNA1C gene is associated with increased risk for bipolar disorder (BD) and variations in brain morphology and function of subcortical regions. Here we sought to investigate the influence of CACNA1C polymorphism on key subcortical brain structures implicated in the pathophysiology of BD.

Methods

Structural magnetic resonance imaging scans were acquired from 41 euthymic patients with BD and 40 healthy controls, who were also genotyped for the CACNA1C rs1006737 polymorphism. The effect of diagnosis, genotype and their interaction was examined in predefined volumes of interest in the basal ganglia, hypothalamus and amygdala extracted using SPM5.

Results

Carriers of the CACNA1C rs1006737 risk allele showed increased grey matter density in the right amygdala and right hypothalamus irrespective of diagnosis. An interaction between genotype and diagnosis was observed in the left putamen which was smaller in BD patients carrying the risk allele than in healthy controls.

Conclusions:

The CACNA1C rs1006737 polymorphism influences anatomical variation within subcortical regions involved in emotional processing.

Keywords

CACNA1CPutamenBasal gangliaAmygdalaHypothalamusBipolar disorderStructuralNeuroimaging
Type
Short communication
Information
European Psychiatry , Volume 26 , Issue 3 , April 2011 , pp. 135 - 137
Copyright
Copyright © Elsevier Masson SAS 2011

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